Herbert L Bonkovsky Selected Research

Porphobilinogen

3/2023	Recurrent symptoms of acute intermittent porphyria after biochemical normalization with givosiran-An ongoing clinical conundrum.
1/2022	Efficacy and safety of givosiran for acute hepatic porphyria: 24-month interim analysis of the randomized phase 3 ENVISION study.
11/2020	Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria.
1/2019	Phase 1 Trial of an RNA Interference Therapy for Acute Intermittent Porphyria.
9/2015	Acute Porphyrias.
11/2014	Clinically important features of porphyrin and heme metabolism and the porphyrias.
7/2013	Circadian rhythms in acute intermittent porphyria--a pilot study.

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Herbert L Bonkovsky Research Topics

Disease

46	Fibrosis (Cirrhosis) 01/2019 - 12/2002
39	Hepatitis C 01/2019 - 04/2004
38	Chronic Hepatitis C 01/2023 - 12/2002
28	Liver Diseases (Liver Disease) 01/2023 - 02/2002
24	Chemical and Drug Induced Liver Injury 03/2024 - 01/2009
20	Porphyrias (Porphyria) 01/2024 - 11/2004
20	Acute Intermittent Porphyria (Porphyria, Acute) 03/2023 - 01/2005
20	Hepatocellular Carcinoma (Hepatoma) 06/2019 - 09/2005
17	Infections 04/2015 - 12/2002
13	Hepatic Porphyrias (Hepatic Porphyria) 01/2023 - 01/2005
11	Erythropoietic Protoporphyria 12/2023 - 02/2002
9	Pain (Aches) 01/2023 - 03/2005
9	Hepatitis 12/2017 - 01/2002
7	Porphyria Cutanea Tarda 01/2023 - 04/2002
7	Liver Cirrhosis (Hepatic Cirrhosis) 01/2019 - 03/2005
6	Variegate Porphyria (Protoporphyrinogen Oxidase Deficiency) 01/2023 - 01/2005
6	Hereditary Coproporphyria (Coproporphyrinogen Oxidase Deficiency) 01/2023 - 01/2005
6	Disease Progression 09/2012 - 10/2004
6	Iron Overload 07/2012 - 04/2002
4	Hyponatremia 01/2023 - 01/2005
4	Neoplasms (Cancer) 11/2020 - 01/2011
4	Acute Liver Failure (Fulminant Hepatic Failure) 01/2019 - 11/2009
3	Non-alcoholic Fatty Liver Disease 09/2019 - 06/2003
3	Pancreatic Neoplasms (Pancreatic Cancer) 12/2013 - 01/2011
3	Chronic Hepatitis (Chronic Active Hepatitis) 08/2013 - 07/2010
3	Hemochromatosis (Bronze Diabetes) 07/2012 - 03/2005
3	Virus Diseases (Viral Diseases) 11/2010 - 02/2007
2	Hypertension (High Blood Pressure) 04/2024 - 01/2023
2	Inborn Genetic Diseases (Disease, Hereditary) 12/2023 - 01/2020
2	Anemia 12/2022 - 11/2014
2	Jaundice (Icterus) 04/2022 - 07/2002
2	Weight Loss (Weight Reduction) 01/2022 - 09/2013
2	Seizures (Absence Seizure) 01/2022 - 01/2013
2	Body Weight (Weight, Body) 11/2020 - 01/2019
2	Type 2 Diabetes Mellitus (MODY) 09/2019 - 07/2002
2	Fatty Liver 09/2019 - 08/2016
2	Insulin Resistance 09/2019 - 06/2003
2	End Stage Liver Disease 01/2019 - 06/2003
2	Necrosis 01/2018 - 06/2013
2	Cholestasis 11/2017 - 01/2017
2	Hepatitis B 10/2014 - 03/2007
2	Autoimmune Hepatitis 05/2014 - 09/2006
2	Hypergammaglobulinemia (Hyperimmunoglobulinemia) 05/2014 - 09/2006
2	Ascites 05/2011 - 01/2010
2	Hemorrhage 05/2011 - 01/2010

Drug/Important Bio-Agent (IBA)

34	Antiviral Agents (Antivirals)IBA 03/2015 - 04/2004
31	Heme (Haem)IBA 01/2024 - 02/2002
25	Ribavirin (Virazole)FDA LinkGeneric 04/2012 - 04/2004
20	IronIBA 12/2022 - 01/2002
17	InterferonsIBA 02/2013 - 04/2004
12	Dyphylline (Diprophylline)FDA Link 01/2023 - 01/2009
11	Proteins (Proteins, Gene)FDA Link 01/2019 - 07/2006
9	RNA (Ribonucleic Acid)IBA 01/2019 - 04/2004
7	protoporphyrin IXIBA 12/2023 - 12/2005
7	PorphyrinsIBA 03/2023 - 11/2004
7	PorphobilinogenIBA 03/2023 - 07/2013
7	givosiranIBA 03/2023 - 01/2019
7	Hemin (Panhematin)FDA Link 01/2023 - 01/2005
6	AcidsIBA 03/2023 - 11/2005
6	Hydro-Lyases (Dehydratases)IBA 01/2023 - 01/2005
6	Biomarkers (Surrogate Marker)IBA 01/2019 - 03/2008
6	MicroRNAs (MicroRNA)IBA 01/2017 - 11/2010
5	Messenger RNA (mRNA)IBA 01/2019 - 04/2002
5	Heme Oxygenase-1IBA 10/2015 - 07/2006
4	EnzymesIBA 12/2023 - 02/2002
4	Ferrochelatase (Heme Synthetase)IBA 12/2023 - 02/2002
4	Acute Hepatic PorphyriaIBA 01/2022 - 01/2020
4	Aminolevulinic Acid (Levulan)FDA Link 01/2022 - 11/2014
4	Transaminases (Aminotransferases)IBA 11/2020 - 07/2002
4	AlbuminsIBA 01/2017 - 02/2002
4	peginterferon alfa-2a (Pegasys)FDA Link 12/2008 - 04/2004
3	CreatinineIBA 01/2023 - 11/2020
3	TeaIBA 01/2022 - 11/2009
3	Hydroxymethylbilane Synthase (Porphobilinogen Deaminase)IBA 11/2019 - 11/2019
3	CytokinesIBA 01/2019 - 01/2013
3	AntioxidantsIBA 12/2015 - 03/2009
3	BilirubinIBA 12/2015 - 03/2007
3	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 08/2014 - 09/2006
3	Cytidine Triphosphate (CTP)IBA 08/2011 - 10/2010
3	SilymarinIBA 04/2011 - 02/2008
3	Ferritins (Ferritin)IBA 11/2010 - 03/2005
3	DNA (Deoxyribonucleic Acid)IBA 11/2009 - 02/2007
2	Isoniazid (Ftivazide)FDA LinkGeneric 04/2024 - 12/2017
2	MetalsIBA 04/2023 - 12/2015
2	HLA Antigens (Human Leukocyte Antigens)IBA 01/2023 - 08/2019
2	Anticonvulsants (Antiepileptic Drugs)IBA 04/2022 - 01/2022
2	Phenobarbital (Luminal)FDA Link 01/2022 - 11/2005
2	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2017 - 05/2014
2	afamelanotideIBA 01/2016 - 07/2015
2	HepcidinsIBA 10/2015 - 07/2012
2	AutoantibodiesIBA 05/2014 - 11/2009
2	Antimalarials (Antimalarial Agents)IBA 07/2012 - 02/2007
2	CollagenIBA 07/2012 - 03/2008
2	Aspartate Aminotransferases (Aspartate Transaminase)IBA 10/2011 - 01/2010
2	Alanine Transaminase (SGPT)IBA 10/2011 - 01/2010
2	Estrogens (Estrogen)FDA Link 01/2011 - 02/2007
2	Ethanol (Ethyl Alcohol)IBA 01/2011 - 06/2008

Therapy/Procedure

41	Therapeutics 12/2022 - 09/2002
12	Liver Transplantation 01/2022 - 02/2002
3	Retreatment 01/2007 - 11/2006